RxBNEylea
aflibercept
1 reference · 2 interchangeable · 5 biosimilar-only
Reference Product
Eylea
aflibercept
351(a) Reference Product (Approval Date 18-Nov-2011)
ApplicantRegeneron Pharmaceuticals, Inc.
BLA125387
RouteIntravitreal
Presentation
Pre-Filled SyringeSingle-Dose Vial
Eylea
aflibercept
351(a) Reference Product (Approval Date 18-Nov-2011)
ApplicantRegeneron Pharmaceuticals, Inc.
BLA125387
·RouteIntravitreal
Presentation
Pre-Filled SyringeSingle-Dose Vial
Interchangeable Biosimilars
Opuviz
aflibercept-yszy
351(k) Interchangeable Biosimilar (Interchangeable Approval Date 20-May-2024)
ApplicantSamsung Bioepis Co., Ltd.
BLA761350
RouteIntravitreal
Presentation
Single-Dose Vial
Opuviz
aflibercept-yszy
351(k) Interchangeable Biosimilar (Interchangeable Approval Date 20-May-2024)
ApplicantSamsung Bioepis Co., Ltd.
BLA761350
·RouteIntravitreal
Presentation
Single-Dose Vial
Yesafili
aflibercept-jbvf
351(k) Interchangeable Biosimilar (Interchangeable Approval Date 20-May-2024)
ApplicantBiocon Biologics Inc.
BLA761274
RouteIntravitreal
Presentation
Single-Dose Vial
Yesafili
aflibercept-jbvf
351(k) Interchangeable Biosimilar (Interchangeable Approval Date 20-May-2024)
ApplicantBiocon Biologics Inc.
BLA761274
·RouteIntravitreal
Presentation
Single-Dose Vial
Biosimilars (not interchangeable)
Ahzantive
aflibercept-mrbb
351(k) Biosimilar (Approval Date 28-Jun-2024)
ApplicantFormycon AG
BLA761378
RouteIntravitreal
Presentation
Pre-Filled SyringeSingle-Dose Vial
Ahzantive
aflibercept-mrbb
351(k) Biosimilar (Approval Date 28-Jun-2024)
ApplicantFormycon AG
BLA761378
·RouteIntravitreal
Presentation
Pre-Filled SyringeSingle-Dose Vial
Enzeevu
aflibercept-abzv
351(k) Biosimilar (Approval Date 9-Aug-2024)
ApplicantSandoz Inc.
BLA761382
RouteIntravitreal
Presentation
Pre-Filled SyringeSingle-Dose Vial
Enzeevu
aflibercept-abzv
351(k) Biosimilar (Approval Date 9-Aug-2024)
ApplicantSandoz Inc.
BLA761382
·RouteIntravitreal
Presentation
Pre-Filled SyringeSingle-Dose Vial
Eydenzelt
aflibercept-boav
351(k) Biosimilar (Approval Date 2-Oct-2025)
ApplicantCELLTRION, Inc.
BLA761377
RouteIntravitreal
Presentation
Pre-Filled SyringeSingle-Dose Vial
Eydenzelt
aflibercept-boav
351(k) Biosimilar (Approval Date 2-Oct-2025)
ApplicantCELLTRION, Inc.
BLA761377
·RouteIntravitreal
Presentation
Pre-Filled SyringeSingle-Dose Vial
Pavblu
aflibercept-ayyh
351(k) Biosimilar (Approval Date 23-Aug-2024)
ApplicantAmgen Inc.
BLA761298
RouteIntravitreal
Presentation
Pre-Filled SyringeSingle-Dose Vial
Pavblu
aflibercept-ayyh
351(k) Biosimilar (Approval Date 23-Aug-2024)
ApplicantAmgen Inc.
BLA761298
·RouteIntravitreal
Presentation
Pre-Filled SyringeSingle-Dose Vial
Yesafili
aflibercept-jbvf
351(k) Biosimilar (Approval Date 13-Jan-2026)
ApplicantBiocon Biologics Inc.
BLA761274
RouteIntravitreal
Presentation
Pre-Filled Syringe
Yesafili
aflibercept-jbvf
351(k) Biosimilar (Approval Date 13-Jan-2026)
ApplicantBiocon Biologics Inc.
BLA761274
·RouteIntravitreal
Presentation
Pre-Filled Syringe